A Selective Nano Cell Cycle Checkpoint Inhibitor Overcomes Leukemia Chemoresistance (Small 25/2023)

Nano Cell Cycle Checkpoint Inhibitors In article number 2300736, Daishun Ling, Fangyuan Li, and co-workers demonstrate that ultra-small iron oxide nanoparticles (IONPs) can serve as a selective nano cell cycle checkpoint inhibitor (NCCI) to catalyze the intracellular H2O2 into abundant ·OH, cleave heat shock protein 90 (Hsp90), thus induce degradation of client ATR/CHK1, leading dysfunction G2/M in acute myeloid leukemia (AML) cells. As result, NCCI interfere with chemotherapy-induced DNA damage repair, which effectively reverses chemoresistance leukemia.